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Metformin Mechanism of action Metformin can cause weight loss primarily due to its effects on appetite regulation via the hypothalamus, thereby reducing the number of calories that you ingest

2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Moher et al., 2009) and the guidelines from the Cochrane Handbook for Systematic Reviews of Interventions (Supplementary Table S1

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